You will find there's release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to decrease afferent agony transmission and create analgesia. For that reason, drugs like clonidine that focus on alpha-two receptors can affect the transmission of suffering. Jun 10, 2024 https://www.proleviate.com/post/the-new-pain-killer-conolidine