Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals through the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have identified recurrent mutations in genes regulating tumor mobile-microenvironmen... https://bobc576rod5.atualblog.com/profile